Table 2. Loss of Plrx function does not impair Plasmodium life cycle progression.

		sporozoites			prepatency(days)e
Parasite	Infectivitya	midgutb	salivary glandc	liver stagesd	after i.v. injection	by bite
Plrx(-) f	74.1% (±9.7%)	17,100 (±27,200)	6,700 (±3,100)	344 (±1.4)	12/12 (d. 3.7)	10/10 (d. 5.7)
WT	88.8% (±1.8%)	13,900 (±10,300)	16,300 (±3,600)	N/D	8/8 (d. 3.8)	8/8 (d. 5.5)

^aPercentage of mosquitoes that contain oocysts at day 11–13 post-feeding.

^bMidgut-associated sporozoites per infected mosquito at day 12–14 post-feeding.

^cSalivary gland-associated sporozoites per infected mosquito at day 17–19 post-feeding.

^dLiver stages are mature exo-erythrocytic forms visualized 48 hours after incubation of 10,000 salivary gland sporozoites with subconfluent cultured hepatocytes.

^ePrepatent period is the time until the first detection of an erythrocytic stage parasite in Giemsa-stained blood smears after intravenous injection of 10,000 salivary gland sporozoites (i.v.) or by bites of 5–10 infected mosquitoes.

^fFour independent Plrx(-) clones (# 1,2,5, and 7) were fed. Shown are the average values from these phenotypically indistinguishable clones.

N/D, not done.