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. Author manuscript; available in PMC: 2008 Jun 15.
Published in final edited form as: Minerva Med. 2007 Dec;98(6):731–747.

Figure 1.

Figure 1

SDS agarose gel electrophoresis comparing the multimeric compositions of endothelial and plasma VWF. VWF is visualized by probing with rabbit anti-VWF and 125I-labeled goat anti-rabbit IgG. A: endothelial secreted VWF consists of a single band that is much larger than the largest forms in plasma VWF multimers. B: The VWF compositions in the plasma samples from a patient of TTP during remission (Rem) and the same patient during acute relapse (Acute) are compared with those in three normal plasma samples (NP). Both plasma samples have ultra large multimers because their ADAMTS13 activity levels are decreased (15% and <10% respectively). In acute TTP, the ultra and large multimers are decreased because they are consumed in the process of VWF-platelet binding.