TABLE-1.
Metabolic profile of animals
| ApoE+/−-IL-6+/− | ApoE+/−-IL-6+/− | ApoE+/−-IL-6+/− | ApoE+/−-IL-6+/− | |||
|---|---|---|---|---|---|---|
| 1. Serum lipids and glucose level in mice fed with chow diet and receiving vehicle (normal saline) | ||||||
| Duration (weeks) | 14 | 14 | P value* | 24 | 24 | P values* |
| Number of mice (n) | 8 | 8 | 8 | 8 | ||
| Weight (g) | 28.1±4 | 29.3±5 | 30.3±4 | 31.3±2 | ||
| Total cholesterol (mg/dl) | 180.2±12 | 198.2±11 | >0.05 | 195.8±10 | 205±15 | >0.05 |
| HDL (mg/dl) | 34±12 | 28±5 | >0.05 | 35.3±5 | 30±8 | >0.05 |
| LDL (mg/dl) | 41±7 | 46±4 | >0.05 | 48.5±11 | 54.1±9 | >0.05 |
| Glucose (mg/dl) | 78.5±12 | 87.9±14 | >0.05 | 91.4±16 | 93.3±3 | >0.05 |
| 2. Serum lipids and glucose level in mice fed with chow diet and receiving P. gingivalis | ||||||
| Duration (weeks) | 14 | 14 | P value* | 24 | 24 | P value* |
| Number of mice (n) | 8 | 8 | 8 | 8 | ||
| Weight (g) | 30.1±4 | 31.1±2 | 31.7±3 | 31.0±3 | ||
| Total cholesterol (mg/dl) | 201.1±13 | 258.9±18 | <0.05 | 264.6±10 | 331.6±11 | <0.05 |
| HDL (mg/dl) | 67±9 | 48.9±5 | <0.05 | 56±4 | 40.6±9 | <0.05 |
| LDL (mg/dl) | 52±6 | 69±3 | <0.05 | 59.9±8 | 84.5±11 | <0.05 |
| Glucose (mg/dl) | 93.3±5 | 115.9±12 | >0.05 | 119.3±16 | 133±10 | >0.05 |
| 3. Serum lipids and glucose level in mice fed with high fat diet and receiving vehicle (normal saline) | ||||||
| Duration (weeks) | 14 | 14 | P valve* | 24 | 24 | P value* |
| Number of mice (n) | 8 | 8 | 8 | 8 | ||
| Weight (g) | 30.1±4 | 29.1±5 | 30.1±6 | 31.1±4 | ||
| Total cholesterol (mg/dl) | 609±11 | 811.3±10 | <0.05 | 806.13±14 | 1069.3±13 | <0.05 |
| HDL (mg/dl) | 106.1±11 | 88±12 | <0.05 | 99.6±4 | 70±8 | <0.05 |
| LDL (mg/dl) | 114.5±6 | 151±6 | <0.05 | 143.9±5 | 208.5±9 | <0.05 |
| Glucose (mg/dl) | 125±7 | 166.6±9 | <0.05 | 134±10 | 179±15 | <0.05 |
| 4. Serum lipids and glucose level in mice fed with high fat diet and receiving P. giugivalis | ||||||
| Duration (weeks) | 14 | 14 | P value* | 24 | 24 | P value* |
| Number of mice (n) | 8 | 8 | 8 | 8 | ||
| Weight (g) | 29.1±3 | 30.1±2 | 31.1±2 | 32.1±1.2 | ||
| Total cholesterol (mg/dl) | 645.67±16 | 909±11 | <0.05 | 819.13±14 | 1135±18 | <0.05 |
| HDL (mg/dl) | 154±6 | 80.8±11 | <0.05 | 117±10 | 76±9 | <0.05 |
| LPL (mg/dl) | 142.8±6 | 197.2±10 | <0.05 | 168.6±11 | 249.6±9 | <0.05 |
| Glucose (mg/dl) | 140.3±13 | 182.9±14 | <0.05 | 149±21 | 195±15 | <0.05 |
*
Significance between ApoE+/−-IL-6+/− and ApoE+/−-IL-6+/− for respective groups. Abbreviattions are as defined in the text.