Table 1.
Characteristics of ovarian cancer cases
| Total | SEARCH | FROC | MALOVA | |
|---|---|---|---|---|
| Total no. subjects | 1,499 | 726 | 327 | 446 |
| Total time at risk, person-years | 6,013 | 2,998 | 1,210 | 1,804 |
| Median follow-up, y* | 6.15 (0.01-10)† | 7.61 (1.89-10) | 4.54 (0.27-8.27) | 3.27 (0.01-9.72) |
| Median time at risk, y | 4.16 (0.00-9.72)† | 4.69 (0.10-6.58) | 3.67 (0.00-7.74) | 3.26 (0.01-9.72) |
| Median time from diagnosis to study entry, y | 1.39 (0.00-8.77)† | 2.7 (0.34-8.77) | 0.55 (0.15-4.04) | 0.00 (0.00-0.32) |
| No. deaths | 637 | 189 | 147 | 301 |
| Annual mortality rate | 0.11 | 0.063 | 0.12 | 0.17 |
| Median 5-y survival (95% CI), % | 48 (44-51)‡ | 72 (68-77) | 52 (45-58) | 40 (35-44) |
| Median age at diagnosis, y | 56 (21-80)† | 56 (21-74) | 51 (23-64) | 60 (32-80) |
| Age at diagnosis (y), n (%) | ||||
| <40 | 102 (7) | 50 (7) | 39 (12) | 13 (3) |
| 40-49 | 297 (20) | 130 (18) | 96 (29) | 71 (16) |
| 50-59 | 529 (35) | 273 (38) | 126 (39) | 130 (29) |
| >60 | 571 (38) | 273 (38) | 66 (20) | 232 (52) |
| Total | 1,499 (100) | 726 | 327 | 446 |
| Histopathologic type,§ n (%) | ||||
| Serous | 698 (51) | 257 (40) | 166 (58) | 275 (62) |
| Endometrioid | 234 (17) | 131 (20) | 47 (16) | 56 (13) |
| Mucinous | 169 (12) | 97 (15) | 29 (10) | 43 (10) |
| Clear cell | 118 (9) | 62 (10) | 23 (8) | 33 (7) |
| Papillary NOS | 77 (6) | 38 (6) | 9 (3) | 30 (7) |
| Other | 78 (6) | 57 (9) | 13 (5) | 8 (2) |
| Total known | 1,374 | 726 | 327 | 445 |
| Unspecified | 125 | 84 | 40 | 1 |
| Clinical stage, n (%) | ||||
| Localized tumor | 561 (37) | 291 (40) | 122 (37) | 148 (33) |
| Advanced disease∥ | 629 (42) | 143 (20) | 188 (57) | 298 (67) |
| Total known | 1,190 | 434 | 310 | 446 |
| Unknown | 309 | 292 | 17 | 0 |
| Grade, n (%) | ||||
| Well differentiated | 251 (17) | 102 (14) | 45 (14) | 104 (23) |
| Moderately differentiated | 376 (25) | 167 (23) | 64 (20) | 145 (33) |
| Poorly/undifferentiated | 504 (34) | 182 (25) | 154 (47) | 168 (38) |
| Total known | 1,131 | 451 | 263 | 417 |
| Unknown | 368 | 275 | 64 | 29 |
*
Follow-up censored at 10 y.
†
Range of variable.
‡
95% CI.
§
The calculation of percentage of histopathologic subtype was using the number of total known as denominator in each column respectively.
∥
Spread to regional lymph nodes or distant metastases.