TABLE I.

Association between Leptin (LEP) and Leptin Receptor (LEPR) Genotypes and Colon Cancer

	LEPR (rs6588147)
						AA				AG				GG
		Controls (n)	Cases (n)	OR1	95% CI	Controls (n)	Cases (n)	OR	95% CI	Controls (n)	Cases (n)	OR	95% CI	Controls (n)	Cases (n)	OR	95% CI
Men						477	417	1.00	Reference	454	393	1.00	0.83, 1.21	123	75	0.71	0.52, 0.97
										Combined rs6588147 and rs7799039
LEP rs 7799039	GG	363	287	1.00	Reference	166	146	1.00	Reference	156	118	0.89	0.64, 1.24	37	22	0.70	0.39, 1.25
	GA	487	444	1.19	0.97, 1.46	216	204	1.12	0.83, 1.51	211	200	1.13	1.84, 1.53	58	37	0.76	0.48, 1.23
	AA	210	157	0.98	0.75, 1.27	95	67	0.84	0.57, 1.25	87	74	1.02	0.69, 1.50	28	16	0.68	0.35, 1.32
										Combined rs6588147 and rs2167270
LEP rs2167270	GG	438	349	1.00	Reference	207	160	1.00	Reference	177	162	1.20	0.89, 1.62	54	27	0.66	0.40, 1.10
	GA	452	424	1.18	0.97, 1.43	190	210	1.44	1.08, 1.91	212	174	1.08	0.81, 1.44	48	39	1.07	0.67, 1.71
	AA	165	111	0.84	0.64, 1.11	79	47	0.76	0.50, 1.16	65	54	1.09	0.72, 1.65	21	9	0.56	0.25, 1.26
Women						411	349	1.00	Reference	396	262	0.80	0.64, 0.99	108	80	0.90	0.65, 1.25
										Combined rs6588147 and rs7799039
LEP rs2167270	GG	275	219	1.00	Reference	136	117	1.00	Reference	109	77	0.86	0.59, 1.27	28	24	1.09	0.59, 1.99
	GA	459	345	1.01	0.80, 1.27	183	167	1.10	0.79, 1.53	204	134	0.84	0.60, 1.18	57	42	0.95	0.59, 1.52
	AA	188	129	0.92	0.69, 1.24	81	64	1.01	0.66, 1.53	83	51	0.79	0.51, 1.22	23	14	0.78	0.38, 1.59
										Combined rs6588147 and rs2167270
LEP rs2167270	GG	362	264	1.00	Reference	159	139	1.00	Reference	158	98	0.73	0.52, 1.02	44	27	0.73	0.43, 1.25
	GA	417	345	1.14	0.92, 1.42	185	169	1.06	0.78, 1.44	178	134	0.89	0.65, 1.23	51	40	0.93	0.58, 1.50
	AA	139	84	0.82	0.60, 1.13	66	39	0.67	0.42, 1.06	59	30	0.59	0.36, 0.97	13	13	1.20	0.54, 2.67
Everyone						881	759	1.00	Reference	848	650	0.91	0.79, 1.05	230	155	0.81	0.64, 1.02
										Combined rs6588147 and rs7799039
LEP rs7799039	GG	634	499	1.00	Reference	301	260	1.00	Reference	265	193	0.88	0.69, 1.14	65	46	0.88	0.58, 1.34
	GA	938	782	1.13	0.97, 1.33	408	368	1.13	0.90, 1.42	414	332	1.03	0.82, 1.29	114	79	0.89	0.63, 1.25
	AA	393	284	0.98	0.80, 1.19	172	130	0.95	0.71, 1.28	169	124	0.92	0.68, 1.23	51	30	0.75	0.46, 1.22
										Combined rs6588147 and rs2167270
LEP rs2167270	GG	794	611	1.00	Reference	361	297	1.00	Reference	335	260	0.96	0.76, 1.20	97	54	0.70	0.49, 1.02
	GA	867	766	1.17	1.01, 1.35	375	378	1.24	1.00, 1.53	369	307	1.00	0.80, 1.24	99	79	1.02	0.72, 1.42
	AA	304	190	0.79	0.64, 0.98	145	84	0.69	0.50, 0.94	124	83	0.81	0.59, 1.12	34	22	0.79	0.45, 1.39

¹Adjusted for 5-year age group and race; everyone also adjusted for sex.