TABLE II.
Association between BMI and Leptin (LEP) and Leptin Receptor (LEPR) Gene Polymorphisms and Colon Cancer Risk
| BMI |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal (<25 kg/m2) |
Overweight (25 to <30 kg/m2) |
Obese (≥30 kg/m2) |
||||||||||
| Controls (n) | Cases (n) | OR1 | 95%CI | Controls (n) | Cases (n) | OR | 95%CI | Controls (n) | Cases (n) | OR | 95%CI | |
| Men and women recently exposed to estrogen2 | ||||||||||||
| LEPR (rs6588147) | ||||||||||||
| AA | 241 | 161 | 1.00 | 277 | 215 | 1.21 | 0.92, 1.59 | 105 | 148 | 2.04 | 1.47, 2.83 | |
| AG | 220 | 143 | 1.01 | 0.75, 1.35 | 282 | 210 | 1.17 | 0.89, 1.53 | 115 | 134 | 1.78 | 1.29, 2.45 |
| GG | 71 | 24 | 0.51 | 0.31, 0.85 | 65 | 47 | 1.16 | 0.76, 1.79 | 39 | 25 | 0.95 | 0.55, 1.65 |
| p interaction | 0.25 | |||||||||||
| LEP (rs 7799039) | ||||||||||||
| GG | 155 | 97 | 1.00 | 223 | 149 | 1.06 | 0.76, 1.48 | 85 | 103 | 1.80 | 1.22, 2.67 | |
| GA | 279 | 167 | 0.95 | 0.69, 1.31 | 289 | 233 | 1.33 | 0.98, 1.82 | 109 | 153 | 2.22 | 1.55, 3.17 |
| AA | 99 | 65 | 1.04 | 0.69, 1.56 | 118 | 93 | 1.32 | 0.91, 1.93 | 66 | 51 | 1.19 | 0.76, 1.87 |
| p interaction | 0.11 | |||||||||||
| LEP (rs 2167270) | ||||||||||||
| GG | 217 | 139 | 1.00 | 250 | 186 | 1.23 | 0.92, 1.64 | 111 | 113 | 1.59 | 1.13, 2.23 | |
| GA | 243 | 159 | 1.07 | 0.79, 1.43 | 274 | 228 | 1.38 | 1.04, 1.83 | 108 | 144 | 2.07 | 1.48, 2.88 |
| AA | 73 | 29 | 0.63 | 0.39, 1.03 | 101 | 59 | 0.93 | 0.63, 1.37 | 40 | 49 | 1.87 | 1.16, 3.02 |
| p interaction | 0.08 | |||||||||||
1
Odds ratios and 95% confidence intervals adjusted for 5-year. age category, sex and race.
2
Women recently exposed to estrogen are defined as those women who were premenopausal or who had taken HRT within the past 2 years.