TABLE III.
Asssociation between Aspirin/NSAIDS use, Leptin (LEP) and Leptin Receptor (LEPR) and Colon Cancer Risk
| Aspirin/NSAID Use |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Aspirin/NSAIDS | Controls (n) | Cases (n) | OR1 No current use | 95% CI | Controls (n) | Cases(n) | OR Current use | 95% CI | |
| LEPR (rs6588147) | AA | 531 | 528 | 1.00 | 357 | 238 | 0.67 | 0.55, 0.83 | |
| AG | 496 | 449 | 0.92 | 0.78, 1.10 | 354 | 206 | 0.60 | 0.48, 0.74 | |
| GG | 129 | 109 | 0.88 | 0.78, 1.16 | 102 | 46 | 0.46 | 0.32, 0.67 | |
| p interaction | 0.38 | ||||||||
| LEP (rs7799039) | GG | 358 | 358 | 1.00 | 280 | 150 | 0.55 | 0.43, 0.70 | |
| GA | 555 | 540 | 1.03 | 0.85, 1.25 | 391 | 249 | 0.67 | 0.54, 0.84 | |
| AA | 250 | 191 | 0.82 | 0.64, 1.04 | 148 | 95 | 0.68 | 0.50, 0.91 | |
| p interaction | 0.04 | ||||||||
| LEP (rs2167270) | GG | 484 | 407 | 1.00 | 316 | 206 | 0.77 | 0.62, 0.96 | |
| GA | 502 | 544 | 1.29 | 1.08, 1.55 | 367 | 225 | 0.74 | 0.59, 0.91 | |
| AA | 171 | 135 | 0.93 | 0.71, 1.20 | 133 | 60 | 0.54 | 0.39, 0.75 | |
| p interaction | 0.04 | ||||||||
1
Odds ratios (OR) and 95% confidence intervals (CI) adjusted for age, sex, race and center.