TABLE IV.

Associations between Insulin-Related Genes, Leptin (LEP), Leptin Receptor (LEPR) and Colon Cancer Risk

	IGF1
	19/19				19/non 19				non 19/non 19
	Controls (n)	Cases (n)	OR	95%CI	Controls (n)	Cases (n)	OR	95%CI	Controls (n)	Cases (n)	OR	95%CI
LEPR (rs6588147)
AA	341	296	1.00		421	354	0.97	0.78, 1.20	114	109	1.00	0.73, 1.37
AG	352	264	0.87	0.70, 1.09	385	292	0.89	0.71, 1.10	102	89	1.02	0.73, 1.42
GG	101	62	0.72	0.50, 1.03	94	74	0.91	0.65, 1.29	28	18	0.78	0.42, 1.46
p interaction	0.55
LEP (rs7799039)
GG	232	192	1.00		294	229	0.93	0.71, 1.21	104	83	0.85	0.59, 1.23
GA	403	322	1.01	0.79, 1.29	436	359	1.03	0.81, 1.31	93	102	1.37	0.97, 1.93
AA	163	112	0.85	0.62, 1.16	176	134	0.97	0.72, 1.31	49	31	0.80	0.49, 1.31
p interaction	0.13
LEP (rs2167270)
GG	331	224	1.00		368	284	1.16	0.92, 1.46	87	91	1.48	1.04, 2.09
GA	358	321	1.37	1.09, 1.72	393	343	1.31	1.05, 1.64	103	101	1.43	1.03, 1.99
AA	108	76	1.02	0.72, 1.44	140	94	0.98	0.71, 1.34	53	24	0.63	0.38, 1.06
p interaction	<0.01
IRS2
LEPR (rs6588147)				GG						GD/DD
AA	380		357	1.00				495	406	0.90		0.74, 1.10
AG	343		287	0.92		0.74, 1.13		499	356	0.79		0.64, 0.96
GG	97		68	0.78		0.55, 1.10		126	85	0.75		0.55, 1.02
p interaction	0.88
LEP (rs7799039)
GG	274		226	1.00				357	273	0.99		0.78, 1.26
GA	384		363	1.24		0.98, 1.57		550	421	1.01		0.81, 1.27
AA	167		126	1.00		0.74, 1.34		220	155	0.93		0.70, 1.23
P interaction	0.44
LEP (rS2 167270)
GG	358		282	1.00				427	323	0.98		0.79, 1.21
GA	334		356	1.36		1.10, 1.69		523	408	1.02		0.83, 1.25
AA	131		75	0.72		0.52, 0.99		171	116	0.88		0.66, 1.17
p interaction	0.04

Odds rations (OR) and 95% confidence intervals (CI) adjusted for age category, sex and race.