TABLE V.

Association between, VDR, Leptin (LEP) and Leptin Receptor (LEPR) and Colon Cancer Risk

	VDR Fok1
	FF				Ff/ff
	Controls (n)	Cases (n)	OR	95% CI	Controls (n)	Cases (n)	OR	95% CI
LEPR (rs6588147)
AA	312	315	1.00		510	405	0.81	0.66, 0.99
AG	289	246	0.86	0.68, 1.08	515	375	0.74	0.60, 0.92
GG	84	56	0.68	0.46, 0.98	130	82	0.65	0.47, 0.90
p interaction	0.45
LEP (rs7799039)
GG	223	232	1.00		373	234	0.63	0.49, 0.81
GA	319	285	0.91	0.71, 1.16	568	457	0.82	0.66, 1.04
AA	145	103	0.73	0.53, 1.00	221	174	0.80	0.61, 1.06
p interaction	<0.01
LEP (rs2167270)
GG	292	228	1.00		444	353	1.04	0.83, 1.30
GA	297	293	1.27	1.00, 1.61	524	428	1.08	0.87, 1.34
AA	96	95	1.26	0.90, 1.76	189	83	0.57	0.42, 0.78
p interaction	<0.01
	VDR Bsm1
	bb				bB/BB
	Controls (n)	Cases (n)	OR1	95% CI	Controls (n)	Cases (n)	OR	95% CI
LEPR (rs6588147)
AA	320	261	1.00		546	492	1.12	0.91, 1.38
AG	297	238	1.01	0.79, 1.28	539	400	0.93	0.76, 1.15
GG	68	63	1.17	0.80, 1.72	153	90	0.75	055, 1.02
p interaction	0.02
LEP (rs7799039)
GG	221	197	1.00		400	303	0.87	0.68, 1.11
GA	318	278	1.05	0.81, 1.35	610	497	0.97	0.77, 1.22
AA	152	89	0.70	0.50, 0.97	233	186	0.96	0.73, 1.26
p interaction	0.04
LEP (rs2167270)
GG	277	211	1.00		504	384	1.01	0.81, 1.27
GA	298	279	1.24	0.98, 1.59	551	478	1.16	0.94, 1.45
AA	113	70	0.82	0.58, 1.16	184	123	0.88	0.66, 1.18
p interaction	0.76

¹Odds ratios (OR) and 95% confidence intervals (CI) adjusted for age, sex, race and center.