Figure 1.

Transcription units for APP transgenic mice. The diagrams are linear representations of the injected expression constructs and are labeled accordingly. Exons of the human Thy-1 gene are illustrated as solid boxes, and stippled boxes indicate sequences of simian virus 40 tumor antigen at the 3′ end of APP 14 and APP 22 constructs. Hatched boxes represent the murine Thy-1 exons used in the APP 23 construct. APP₇₅₁ cDNAs are shown as open boxes with vertical lines marking the positions of the respective Swedish (S) and London (L) FAD mutations.