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Degenerative processes in APP 23 mice. (A and B) Staining for acetylcholinesterase in 12-month-old transgenic and control mice, respectively. A local distortion of cholinergic fibers in the plaque vicinity (A) compared with normal animals (B) can be noted. Neuritic spheroids (arrows) are stained with the neurofilament antibody NF200 (C). The loss of pyramidal neurons in the vicinity of Aβ deposits in area CA3 is shown in D by toluidine blue staining. (Bars = 50 μm.)
