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Phosphorylation of tau in the brains of 12-month-old APP 23 transgenic mice. Immunocytochemistry with antibody AT8 was performed on free floating sections (40 μm) (A and B). Immunostaining reveals fiber-like structures resembling distorted neurites. Qualitatively similar patterns are obtained with the Alz50 antibody (C). [Bars = 100 μm (A) and 10 μm (B and C).]
