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. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: Respir Physiol Neurobiol. 2008 Jan 31;161(2):142–159. doi: 10.1016/j.resp.2008.01.004

Figure 7.

Figure 7

Simulation of the study of Roughton and Root (1946) in which the change in amount of CO in the blood from 10 to 40 min after a short, high-level CO exposure was compared to the amount of CO exhaled during this time. Parameters for subject #120 of the Benignus, et al., (1994) study were used for the simulation. (a) Amount of CO expired as a fraction of the amount lost from blood for various values of DmCO. Dotted lines mark the values reported for the 2 subjects who were studied (Roughton and Root, 1946). (b) Comparison of the net amount of CO lost from blood (solid line) with the amount expired (dotted line) and the net change in amount of CO in muscle tissues (dashed line). Note that for DmCO > ~ 35, more CO is expired than the net loss from the blood.