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. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: Respir Physiol Neurobiol. 2008 Jan 31;161(2):142–159. doi: 10.1016/j.resp.2008.01.004

Figure 9.

Figure 9

Predicted responses of MbCO when PaO2 is sudenly decreased from 225 to 75 Torr (left panels) or from 75 to 25 Torr (right panels) for 3 values of DmCO. In these simulations the subject rebreathes as in Figure 7(a) and, at t = 72 min, the O2 inflow is stopped until PaO2 falls to the desired level. The change from hyperoxia to mild hypoxia (left) results in an insignificant or small decrease in CO content of muscles (%MbCO = average of %MbCO of the two muscle subcompartments), whereas the change from to severe mild hypoxia (right) causes a significant shift of CO into muscle.