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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Osteoarthritis Cartilage. 2007 Oct 22;16(5):624–630. doi: 10.1016/j.joca.2007.09.012

Figure 5. Determination of type of DNA damage induced by IL-1.

Figure 5

Porcine articular chondrocytes cultured in vitro in alginate bead system were exposed to 0 and 10 ng/ml IL-1, with and without the DNA glycosylase enzymes (a) Fpg or (b) Endo III (N = 3, with 50 observations). Fpg reveals oxidized purines, and Endo III reveals oxidized pyrimidines. DNA damage is expressed as the OTM. (Data represents Mean ± SEM; ** = p < 0.01; *** = p < 0.001. *= p < 0.05; ** = p < 0.01; *** = p < 0.001; N = 3 pigs, with 50 observations per group).