Table 3.
Schild slopes for the H3-antagonists
| agonist | iodophenpropit | n | clobenpropit | n | zolatidine | n | conessine | n | thioperamide | n |
| histamine | 1.15 ± 0.04 | 5 | 0.98 ± 0.03 | 3 | 1.01 ± 0.04 | 4 | 1.07 ± 0.03 | 5 | 1.01 ± 0.03 | 4 |
| N-α-methylhistamine | 1.12 ± 0.04 | 5 | 1.08 ± 0.07 | 3 | 1.10 ± 0.12 | 4 | 0.98 ± 0.05 | 4 | 0.98 ± 0.07 | 5 |
| R-α-methylhistamine | 1.14 ± 0.05 | 5 | 1.10 ± 0.06 | 4 | 1.04 ± 0.04 | 3 | 1.00 ± 0.06 | 3 | 1.00 ± 0.05 | 5 |
| S-α-methylhistamine | 1.17 ± 0.04 | 4 | 1.09 ± 0.04 | 3 | 1.10 ± 0.07 | 4 | 1.08 ± 0.04 | 4 | 1.01 ± 0.08 | 6 |
| Imetit | 1.09 ± 0.04 | 5 | 1.02 ± 0.04 | 4 | 1.17 ± 0.05 | 4 | 1.18 ± 0.09 | 4 | 1.02 ± 0.07 | 3 |
| immepip | 1.13 ± 0.04 | 4 | 1.05 ± 0.02 | 4 | 1.18 ± 0.08 | 4 | 1.09 ± 0.05 | 4 | 1.06 ± 0.02 | 4 |
| immethridine | 1.28 ± 0.13 | 4 | 1.02 ± 0.04 | 4 | 0.96 ± 0.02 | 4 | 1.14 ± 0.08 | 3 | 1.08 ± 0.04 | 4 |
| proxyfan | * | * | 0.91 ± 0.11 | 3 | * | 1.02 ± 0.03 | 3 |
Slope of the Schild plot from antagonism of those compounds where 3 different concentrations of antagonists were possible as determined from measurements of CRE-SPAP production from CHO-H3-SPAP cells. Values represent mean ± s.e.mean of n separate experiments.
* Schild plots were not obtained. Schild plots were also not obtained when impentamine and VUF 8430 were agonists