Table 4.
pKD values for clobenproprit and thioperamide
| pKD | pKD | |||
| agonist | clobenpropit | n | thioperamide | n |
| histamine | 9.38 ± 0.12 | 5 | 7.38 ± 0.04 | 4 |
| N-α-methylhistamine | 9.43 ± 0.14 | 5 | 7.28 ± 0.06 | 3 |
| R-α-methylhistamine | 9.36 ± 0.08 | 4 | 7.42 ± 0.09 | 3 |
| S-α-methylhistamine | 9.46 ± 0.08 | 4 | 7.45 ± 0.09 | 3 |
| imetit | 9.28 ± 0.07 | 5 | 7.48 ± 0.13 | 4 |
| immepip | 9.34 ± 0.15 | 5 | 7.46 ± 0.14 | 4 |
| immethridine | 9.32 ± 0.14 | 5 | 7.46 ± 0.13 | 4 |
| proxyfan | 9.32 ± 0.03 | 5 | 7.33 ± 0.09 | 4 |
| VUF 8430 | 9.42 ± 0.10 | 5 | 7.43 ± 0.09 | 4 |
| impentamine | 9.46 ± 0.11 | 4 | 7.54 ± 0.09 | 4 |
| burimamide | 9.25 ± 0.14 | 4 | 7.39 ± 0.12 | 4 |
| VUF 5681 | 9.20 ± 0.09 | 4 | 7.45 ± 0.10 | 4 |
pKD values for clobenpropit and thioperamide as determined from 3H-cAMP accumulation measurements made in the presence of the 12 different agonists. Values represent mean ± s.e.mean of n separate experiments.