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. 2008 May 30;9:24. doi: 10.1186/1471-2172-9-24

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Copyright © 2008 Wong et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Merge of two top scoring IPA networks derived from the list of 184 genes common to both the upregulated LPS-responsive gene list and the upregulated heat shock-responsive gene list. The merged network is depicted in the context of cellular compartments. This upregulated, common LPS/heat shock-responsive network contains two nodes in the extracellular compartment having a high degree of connectivity to other network genes: interleukin-1β (IL1B) and interleukin-8 (IL8). Both the IL1B and IL8 nodes also demonstrate high level connectivity to the NF-κB pathway. Gold lines indicate connectivity between the two merged networks. See text for network derivation, and see Additional file 8 for network gene list and Additional file 4 for network legend.