Table 1.
Brain and hippocampal weights (mean ± SE) by dose group at PNDs 4, 14, and 21 in male and female offspring.
| Male
|
Female
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Dose (ppm) | 0 | 30 | 300 | 1,000 | 0 | 30 | 300 | 1,000 |
| Brain weight (g) | ||||||||
| PND4 (M + F)a | 0.324 ± 0.003 | 0.321 ± 0.005 | 0.328 ± 0.003 | 0.311 ± 0.003 | ||||
| PND14 | 1.139 ± 0.0138 | 1.126 ± 0.0268 | 1.149 ± 0.0129 | 1.100 ± 0.0233 | 1.114 ± 0.0146 | 1.096 ± 0.0221 | 1.104 ± 0.0218 | 1.106 ± 0.0158 |
| PND21 | 1.404 ± 0.0171 | 1.374 ± 0.0311 | 1.394 ± 0.0129 | 1.383 ± 0.0276 | 1.350 ± 0.0146 | 1.369 ± 0.0171 | 1.353 ± 0.0196 | 1.352 ± 0.0242 |
| Hippocampus weight (mg) | ||||||||
| PND14 | 35.0 ± 1.70 | 37.0 ± 1.61 | 36.5 ± 1.83 | 34.7 ± 2.27 | 34.9 ± 1.69 | 35.5 ± 1.72 | 35.7 ± 1.30 | 36.1 ± 1.09 |
| PND21 | 50.2 ± 1.66 | 49.8 ± 2.15 | 47.8 ± 1.45 | 46.9 ± 1.97 | 46.6 ± 1.16 | 45.8 ± 2.37 | 46.6 ± 1.06 | 47.4 ± 1.37 |
Brain and hippocampal weights increased with age; no treatment-related effects of perchlorate exposure were noted (p > 0.05).
a
Because of insufficient samples for each sex on PND4, mean brain weights were calculated per litter, pooling across sex.