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. Author manuscript; available in PMC: 2008 Jun 16.
Published in final edited form as: J Comp Neurol. 2006 Jul 1;497(1):13–31. doi: 10.1002/cne.20968

Figure 4.

Figure 4

A. The overall size of the CN was estimated by measuring the cross-sectional area of the CN in the single largest section taken just posterior to the entrance of the auditory nerve, and tracing the perimeter, as illustrated here in normal adult (A) and neonatally deafened (B) subjects. Scale bar = 0.4 mm. C. The mean CN area was then calculated for the normal adult control group (6.83 mm2) and for the two deafened groups. The two deafened groups had CN cross-sectional areas that were virtually identical to each other (4.84 mm2 for the neonatally deafened group studied at 4 months of age and 4.94 mm2 for the neonatally deafened group studied at about 8 months of age), but the deafened CN were markedly smaller than normal, measuring only about 72% that of normal controls. This difference was highly statistically significant (Student’s t-test, unpaired). D. The dorsal-to-ventral height of the CN was measured to provide a single-dimensional scaling factor that was used to normalize the thickness of SG projections for the smaller CN size in deafened subjects. The CN height was significantly reduced in the deafened group. Error bars indicate standard error of the mean.