Table 2.

P values in the different strata for association of selected SNPs in MAPT with CSF tau and ptau181 levels

Test	MAF	Stratum	n	Tau	Ptau181
rs2471738†	0.19	Total sample	304	0.025	0.0098
		CSF Aβ42 > 500 pg/ml	168	0.45	0.76
		CSF Aβ42 > 500 pg/ml	136	0.021	0.024
rs16940758	0.21	Total sample	304	0.070	0.0068
		CSF Aβ42 > 500 pg/ml	168	0.82	0.23
		CSF Aβ42 < 500 pg/ml	136	0.0098	0.0026
rs2435211†	0.28	Total sample	304	0.025	0.0057
		CSF Aβ42 > 500 pg/ml	168	0.97	0.53
		CSF Aβ42 < 500 pg/ml	136	0.008	0.020
rs3785883	0.22	Total sample	304	0.070	0.0061
		CSF Aβ42 > 500 pg/ml	168	0.65	0.71
		CSF Aβ42 < 500 pg/ml	136	0.0044	0.0011

Minor allele frequency (MAF) and P values for tau and ptau181. Samples were stratified based on CSF Aβ42 levels greater or less than ≈500 pg/ml as an approximation of amyloid deposition (4, 5). Values in boldface indicate P values <0.05.

^†Recessive model.