Table 3.
Haplotype association with CSF tau and ptau181 levels, using UNPHASED
| Name† | Haplotype | Frequency | tau |
ptau181 |
||
|---|---|---|---|---|---|---|
| AddVal | P | AddVal | P | |||
| H2 | 2-1-1-1-1-1 | 0.22 | 0.00 | 0.36 | 0.00 | 0.56 |
| H1I | 1-2-2-1-1-2 | 0.04 | −4.95 | 0.45 | −5.90 | 0.34 |
| H1M | 1-2-2-1-1-1 | 0.03 | 3.34 | 0.21 | 3.45 | 0.42 |
| H1B | 1-2-1-1-1-2 | 0.17 | −1.44 | 0.63 | −1.12 | 0.68 |
| H1C | 1-1-2-1-2-1 | 0.07 | −3.14 | 0.99 | −3.76 | 0.70 |
| H1D | 1-1-2-1-1-2 | 0.05 | −0.76 | 0.31 | 2.53 | 0.32 |
| H1U | 1-1-2-1-1-1 | 0.03 | −8.01 | 0.0009 | −7.51 | 0.0059 |
| H1H | 1-1-1-2-1-2 | 0.06 | 2.22 | 0.023 | 3.05 | 0.017 |
| H1L | 1-1-1-2-1-1 | 0.04 | 2.10 | 0.17 | 1.07 | 0.26 |
| H1E | 1-1-1-1-1-2 | 0.08 | −3.64 | 0.11 | −4.57 | 0.095 |
Haplotypes were estimated from rs1560310, rs1467967, rs242557, rs3785883, rs2471738, and rs7521 (the common allele is represented as ″1,″ the rare allele is represented as a ″2″). For each haplotype with a frequency of >2% in this sample the frequency, additive genetic value and P value for association with CSF tau levels are shown.
†Haplotype names from Pittman et al. (27). Values in boldface indicate P values <0.05.