Table 2.
Summary of outcomes overall plus comparative statistics (intention-to-treat population)
| No AC (n=1554) | SDAC (n=1544) | MDAC (n=1531) |
Odds ratio (95% CI) |
||||
|---|---|---|---|---|---|---|---|
| MDAC vs no AC | SDAC vs no AC | MDAC vs SDAC | |||||
| Died | 105 (6·8%) | 109 (7·1%) | 97 (6·3%) | 0·93 (0·69–1·25)* | 1·05 (0·79–1·40)* | 0·89 (0·66–1·19)* | |
| 0·96 (0·70–1·33)† | 1·11 (0·82–1·52)† | 0·87 (0·64–1·18)† | |||||
| Needing intubation for ventilation | |||||||
| Baseline | 75 | 71 | 66 | ||||
| Follow-up | 76 (4·9%) | 73 (4·7%) | 73 (4·8%) | 0·97 (0·69–1·37)* | 0·97 (0·68–1·36)* | 1·01 (0·71–1·43)* | |
| 0·96 (0·67–1·37)† | 0·96 (0·67–1·37)† | 1·02 (0·71–1·45)† | |||||
| Seizures | |||||||
| Baseline | 9 | 8 | 7 | ||||
| Follow-up | 7 (0·5%) | 13 (0·8%) | 14 (0·9%) | 2·04 (0·77–5·99)* | 1·88 (0·69–5·57)* | 1·09 (0·47–2·52)* | |
| 1·92 (0·75–4·94)‡ | 1·98 (0·78–5·06)‡ | 0·97 (0·44–2·14)‡ | |||||
Data are number or number (%). AC=activated charcoal. SDAC=single-dose activated charcoal. MDAC=multiple-dose activated charcoal.
Exact CIs.
Logistic regression adjusted for stratification factors: severity status on admission (categories asymptomatic=1 [reference category]; symptomatic with Glasgow coma score [GCS] 14/15=2; and symptomatic with GCS <14=3); toxin stated to have been ingested (categories oleander [Thevetia peruviana]=1 [reference category]; organophosphorus or carbamate pesticides=2; organochlorine=3; other or unknown pesticide or paraquat=4; medicine or unknown=5); reported time between poisoning and randomisation (continuous: linear and quadratic terms), hospital site (categories Anuradhapura=1 [reference category]; Kurunegala=2; Polonnaruwa=3); and whether intubated at baseline (categories: no=0 [reference category]; and yes=1).
As † plus term for presence of seizures at baseline (categories: no=0 [reference category]; and yes=1].