. 2008 Feb 16;371(9612):579–587. doi: 10.1016/S0140-6736(08)60270-6

Table 3.

Summary of poison-specific outcomes plus comparative statistics (intention-to-treat population)

		No AC	SDAC	MDAC	Odds ratio (95% CI)
					MDAC vs no AC	SDAC vs no AC	MDAC vs SDAC
Number		441	440	429
Patients with reported organophosphorus or carbamate poisoning needing intubation for ventilation
	Baseline	63	51	48
	Follow-up	53 (12·0%)	48 (10·9%)	50 (11·7%)	0·97 (0·63–1·49)^*	0·90 (0·58–1·39)^*	1·08 (0·69–1·68)^*
					0·90 (0·58–1·41)^†	0·83 (0·54–1·29)^†	1·12 (0·72–1·74)^†
Seizures
	Baseline	7	2	2
	Follow-up	2 (0·5%)	7 (1·6%)	6 (1·4%)	3·11 (0·55–31·67)^*	3·55 (0·67–35·15)^*	0·88 (0·24–3·08)^*
					3·15 (0·61–16·18)^‡	3·44 (0·70–16·81)^‡	0·89 (0·29–2·71)^‡
Number		555	549	540
Patients with reported oleander (Thevetia peruviana) poisoning given cardiac pacing or antitoxin
	Baseline	2	2	1
	Follow-up	101 (18·2%)	101 (18·4%)	85 (15·7%)	0·84 (0·60–1·17)^*	1·01 (0·74–1·40)^*	0·83 (0·60–1·15)^*
					0·85 (0·61–1·18)^§	1·02 (0·74–1·41)^§	0·82 (0·59–1·14)^§

Data are number or number (%). AC=activated charcoal. SDAC=single-dose activated charcoal. MDAC=multiple-dose activated charcoal.

Exact CIs.

^†

Logistic regression adjusted for stratification factors: severity status on admission (categories asymptomatic=1 [reference category]; symptomatic with Glasgow coma score [GCS] 14/15=2; and symptomatic with GCS <14=3); reported time between poisoning and randomisation (continuous: linear and quadratic terms); hospital site (categories: Anuradhapura=1 [reference category]; Kurunegala=2; and Polonnaruwa=3); and whether intubated at baseline (categories: no=0 [reference category]; and yes=1).

^‡

As † plus term for presence of seizures at baseline (categories: no=0 [reference category]; and yes=1).

^§

As † plus term for whether patient received cardiac pacing at baseline (categories: no=0 [reference category]; and yes=1).