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. 2008 Jun 20;118(7):2609–2619. doi: 10.1172/JCI34588

Figure 6. An independent cell-line model of acquired resistance, HN11 GR, is overcome by combined EGFR and IGFIR blockade.

Figure 6

(A) Parental HN11 and HN11 GR cells (see Methods) were subjected to an MTS survival assay in increasing concentrations of gefitinib as in Figure 5. (B) Parental HN11 and HN11 GR cells were treated with the indicated inhibitors for 6 hours and lysed. Lysates were examined by Western blot analyses with the indicated antibodies. (C) Parental HN11 and HN11 GR cells were subjected to an MTS survival assay in increasing concentrations of gefitinib or AEW541 or a combination. When the combination was used, both drugs were used at the identical concentrations during the dose escalation. Error bars show ± SD.