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. Author manuscript; available in PMC: 2008 Jun 17.
Published in final edited form as: Cancer Cell. 2008 May;13(5):432–440. doi: 10.1016/j.ccr.2008.03.005

Figure 3. In Mll-AF9 knockin mice, HSCs and CLPs produce more total and compact myeloid colonies with enhanced self-renewal in vitro than CMPs and GMPs. MLL-AF9 retrovirally transduced GMPs produce the most total and compact myeloid colonies.

Figure 3

a, Total myeloid colony numbers were higher in HSCs and CLPs than in CMPs and GMPs in Mll-AF9 mice after 21-day culture under myeloid conditions. All the Mll-AF9 populations had significantly increased colonies compared to WT. b. Compact colony numbers were higher in HSCs/CLPs than in CMPs/GMPs in Mll-AF9 mice after 21-day culture. No compact colonies were detected in WT mice. Error bars represent standard error of the means. c, Total myeloid colony and compact colony numbers were the highest in MLL-AF9 retrovirally transduced GMP cells compared to the MIG (MSCV-IRES-GFP) vector transduced knockin Mll-AF9 GMPs and other knockin Mll-AF9 GMP controls as labeled. d, MLL-AF9 expression in retrovirally transduced GMPs and knockin Mll-AF9 GMPs. Error bars represent standard error of the means.