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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Surgery. 2007 Aug;142(2):170–179. doi: 10.1016/j.surg.2007.04.015

Figure 4. The adenylate cyclase activator forskolin suppresses wound macrophage phagocytosis.

Figure 4

Macrophages isolated from 120-hour wounds were treated with physiologic norepinephrine, pharmacologic norepinephrine, or forskolin in the presence of phosphodiesterase inhibitor (IBMX) for 18 hours and phagocytosis of E.coli was assessed. Treatment with forskolin suppressed wound macrophage phagocytic efficiency(*p<0.05), although to a lesser degree than treatment with physiologic or pharmacologic doses of norepinephrine (#p<0.05).