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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Surgery. 2007 Aug;142(2):170–179. doi: 10.1016/j.surg.2007.04.015

Figure 5. Norepinephrine-mediated suppression of wound macrophage phagocytosis is mediated by protein kinase A (PKA).

Figure 5

Macrophages isolated from 120-hour wounds were treated with the PKA inhibitor H-89 for two hours prior to treatment with physiologic norepinephrine (NE +, 10−9 M) or pharmacologic norepinephrine (NE ++, 10−6 M) for 18 hours and assessment of phagocytosis of E.coli. PKA blockade alone had no effect on wound macrophage phagocytosis (p=NS, data not shown). PKA inhibition prevented physiologic norepinephrine-mediated suppression of wound macrophage phagocytosis and partially prevented pharmacologic norepinephrine-mediated suppression (p=NS vs. Untreated Control).