Figure 1. Contiguity statistic and thermostability percentiles for natural functional molecules from the Rfam database.

The blue circles represent percentiles calculated from consensus structures and individual sequences, respectively. The red squares represent percentiles for thermostability predictions of molecules folding into the wildtype structures. We used 239 families in which the consensus structure was relatively well conserved among the individual genotypes. The x-axis gives the fraction of random phenotypes that are predicted to be less abundant (or less thermostable) than the actual phenotype, based on a comparison to 500 randomized molecules. The functional taxonomy is determined by the Rfam database.