Figure 2. The effect of BMSCs on RGCs.
A, RGC neurite formation was enhanced after 5 days of co-culturing with BMSCs (10×). B, Synaptophysin, MAP-2 and TGF-β expression were up-regulated in RGCs co-cultured with BMSCs as determined by real-time RT-PCR (p = 0.031, p = 0.023, p = 0.015, respectively). C, RGC survival was increased when co-cultured with BMSCs (p = 0.025) (d) The mean outgrowth of neurites in RGCs co-cultured with BMSCs increased (p = 0.03). *p-values≤0.05. (10 pictures were taken randomly under a regular microscope from culturing cells at different time points. The average relative percent of surviving and outgrowth of RGCs come from at least three separate experiments).