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. Author manuscript; available in PMC: 2008 Jun 18.
Published in final edited form as: Ann N Y Acad Sci. 2007 Aug 14;1121:320–335. doi: 10.1196/annals.1401.001

FIGURE 1.

FIGURE 1

Schematic summarizing proposed roles for the OFC in reversal learning. (A) Historical proposal that output from OFC directly inhibits “prepotent” responses and thus is critical for reversal learning. (B) More recent idea that OFC acts as a highly flexible associative look-up table to guide correct responding and thus is critical for reversal learning. (C) Our proposal that OFC is critical for reversal learning because it facilitates associative learning in other structures, by facilitating the generation of teaching signals when actual outcomes do not match OFC signals of expected outcomes. DS, dorsal striatum; VS, ventral striatum; DA, dopamine; 5-HT, serotonin.