Table 2.

Association of TACR3 SNPs With Study Phenotypes

					Alcohol dependence
SNP ID	Positiona	SNP locationb	MAFc	HWEd	DSM-IVe	ICD-10e	COGAe	DSM-IV Alc Dep no cocainee	DSM-IIIR cocainee,f
[1] rs2757673	104715499	Downstream	0.25	1.00	0.02	0.02	0.11	0.10	0.02
[2] rs4274850	104720470	Downstream	0.19	0.87	0.05	0.01	0.05	0.05	0.11
[3] rs2868397	104720987	Downstream	0.04	0.79	0.26	0.23	0.25	0.61	0.03
[4] rs3857203	104721232	Downstream	0.35	0.55	0.04	0.04	0.16	0.11	0.01
[5] rs4530637	104725838	Downstream	0.34	1.00	0.03	0.02	0.15	0.11	0.01
[6] rs2765	104730215	3′UTR	0.33	0.66	0.03	0.02	0.15	0.19	0.007
rs17033889	104730341	Exon 5, Thr449Ala	0.01	1.00	N/Ag	N/A	N/A	N/A	N/A
[7] rs4580655	104748723	Intron 3	0.34	0.44	0.02	0.03	0.11	0.12	0.009
[8] rs1813782	104750764	Intron 3	0.37	0.79	0.81	0.46	0.95	0.63	0.04
[9] rs11722288	104752399	Intron 3	0.29	0.94	0.02	0.03	0.12	0.04	0.02
[10] rs13134657	104761590	Intron 3	0.11	0.64	0.31	0.70	0.93	0.56	0.35
[11] rs3796975	104764604	Intron 3	0.45	0.44	0.75	0.94	0.85	0.55	0.63
[12] rs12641703	104772136	Intron 3	0.49	0.87	0.20	0.46	0.66	0.19	0.51
[13] rs3796969	104776115	Intron 3	0.37	0.76	0.16	0.60	0.45	0.07	0.12
[14] rs1384401	104784527	Intron 3	0.35	0.05	0.90	0.57	0.62	0.47	0.02
[15] rs3796962	104793714	Intron 3	0.34	0.14	0.70	0.26	0.43	0.71	0.01
rs2276973	104796831	Exon 3, Arg286Lys	0.00	1.00	N/A	N/A	N/A	N/A	N/A
[16] rs11725038	104802382	Intron 1	0.34	0.08	0.90	0.34	0.80	0.39	0.006
[17] rs1351623	104807426	Intron 1	0.17	0.24	0.18	0.92	0.92	0.21	0.12
[18] rs12649621	104814831	Intron 1	0.10	0.70	0.56	0.94	0.95	0.93	0.57
[19] rs3796954	104820021	Intron 1	0.13	0.02	0.43	0.65	0.92	0.40	0.76
[20] rs11097824	104836637	Intron 1	0.10	0.99	0.76	0.55	0.15	1.00	0.49
[21] rs1989933	104844112	Intron 1	0.10	0.68	0.53	0.92	0.91	0.89	0.57
[22] rs1905173	104855551	Intron 1	0.09	0.93	0.52	0.99	0.79	0.93	0.54
[23] rs3733632	104860384	5′UTR	0.20	0.02	0.23	0.85	0.88	0.08	0.71
[24] rs3733631	104860552	Promoter	0.16	0.73	0.52	0.84	0.74	0.63	0.42
[25] rs3775971	104861369	Promoter	0.16	0.67	0.39	0.89	0.91	0.42	0.33
[26] rs17034019	104867106	Upstream	0.10	0.69	0.66	0.83	0.84	0.92	0.46
[27] rs17034020	104870122	Upstream	0.06	1.00	0.88	0.88	0.50	0.60	0.46
[28] rs233992	104876519	Upstream	0.44	0.19	0.12	0.90	0.14	0.16	0.43

^aChromosome positions are based on NCBI Human Genome Assembly v. 36.1.

^bSNP location relative to the exons of TACR3, based on transcript NM_001059.1. Transcription is opposite to the human genome direction.

^cMinor allele frequency in European Americans.

^dp-Value for test of Hardy Weinberg equilibrium.

^ep-Value of avg-PDT statistic for associations between the SNPs and phenotypes shown.

^fNote that 82% of individuals with cocaine dependence were also alcohol dependent.

^gN/A not available due to very low MAF resulting in no power to detect evidence of association.