Table 4.
Association of TACR3 Haplotypes With Alcohol Dependence (DSM-IV)
| SNP [1-3]
|
SNP [2-4]
|
SNP [3-5]
|
SNP [4-6]
|
SNP [5-7]
|
SNP [6-8]
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overtransmission | Aa | Ub | A | U | A | U | A | U | A | U | A | U |
| [1] rs2757673 | G | A | ||||||||||
| [2] rs4274850 | A | C | A | C | ||||||||
| [3] rs2868397 | C | C | C | C | C | C | ||||||
| [4] rs3857203 | G | A | G | A | G | A | ||||||
| [5] rs4530637 | G | A | G | A | G | A | ||||||
| [6] rs2765 | A | G | A | G | A | G | ||||||
| [7] rs4580655 | A | G | A | G | ||||||||
| [8] rs1813782 | A | G | ||||||||||
| [9] rs11722288 | ||||||||||||
| Haplotype (p-value)c | 0.02 | 0.02 | 0.04 | 0.08 | 0.15 | 0.15 | 0.07 | 0.07 | 0.03 | 0.03 | 0.22 | 0.06 |
| Global (p-value)d | 0.02 | 0.05 | 0.15 | 0.07 | 0.03 | 0.18 | ||||||
a
DSM-IV alcohol dependence.
b
Unaffected.
c
p-Value associated with the differential transmission of that haplotype.
d
Global p-value for the PDT using all haplotypes observed with these 3 SNPs.