Anatomical relationships of the OFC (blue) in rats and monkeys. Based on their pattern of connectivity with the mediodorsal thalamus (MD, green), amygdala (orange) and striatum (pink), the orbital and agranular insular areas in rat prefrontal cortex are homologous to the primate OFC. In both species, the OFC receives robust input from sensory cortices and associative information from the amygdala, and sends outputs to the motor system through the striatum. Each box illustrates a representational coronal section. Additional abbreviations: AId, dorsal agranular insula; AIv, ventral agranular insula; c, central; CD, caudate; LO, lateral orbital; m, medial; NAc, nucleus accumbens core; rABL, rostral basolateral amygdala; VO, ventral orbital, including ventrolateral and ventromedial orbital regions; VP, ventral pallidum.