Fig (2).

Progression of neuronal death in AD in various models. The relationship between neurotoxic insults (thin line) and neuronal cell death (bold line) is influenced by the neuroprotective function (dotted line) counteracting to neurotoxic insults (A). The degree of neuronal death is reduced reflecting the degree of insults or neuroprotection by anti-Aβ or neuroprotective treatment at the time of diagnosis (B, C). When treatments start at earlier time point, neuronal death may be prevented (D, E). X- and Y-axis indicate age and degree of each phenomenon, respectively. See text for details.