Table 3.
Extracellular Values of DA and DOPAC in Intact and 6-OHDA Lesioned Cerebral Areas
| Cerebral Area | DA | DOPAC | ||
|---|---|---|---|---|
| Intact | Lesioned | Intact | Lesioned | |
| Medial prefrontal cortex (20) | 2.4 ± 0.3 | 1.9 ± 0.2 80% |
211.8 ± 48.6 | 23.9 ± 3.7 11% |
| Parietal cortex (11) | 1.9 ± 0.3 | 1.6 ± 0.2 84% |
158.6 ± 37.8 | 19.0 ± 3.7 11% |
| Nucleus accumbens (19) | 42.5 ± 7.4 | 3.5 ± 0.6 8% |
2636 ± 371 | 57.3 ± 13.8 2% |
Values are expressed as pg/sample and are the mean ± SEM of the number of rats indicated in parenthesis. Following monolateral 6-OHDA infusion into the VTA, rats were implanted with two probes, one for each cerebral hemisphere, and intact (controlateral to the lesion) vs. lesioned (ipsilateral to the lesion) side values are compared.