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Sensitization of a colonic dorsal root ganglion cell by PGE2. Bath application of 1 μM PGE2 decreases the action potential threshold (top) and increases the number of action potentials elicited by a suprathreshold stimulus (bottom). The resting potential was -57 mV before PGE2. Hyperpolarizing current was used to maintain the membrane potential at -57 mV after PGE2 application. From [34].
