Table 1.

EP Receptor Subtypes Mediating the PGE₂ Effect on Different Preparations

Receptor	Preparation	Effect	Mimicked by	Reference
EP1/3	melanotrophs	inhibition of ICa	sulprostone	[111]
EP1/4	TRPV1 channel and dorsal root ganglion	enhancement of capsaicin effect	ONO-DI-004	[76]
EP2	spinal dorsal horn	depolarization	butaprost	[4]
EP2	spinal dorsal horn	block of inhibitory glycin receptors	butaprost	[3]
EP2	nodose and jugular ganglion	action potential firing	butaprost	[59]
EP2/4	nodose ganglion	increase in TTX-R INa	ONO-AE1-259 ONO-AE1-329	[67]
EP2/4	osteoclasts	activation of ICl	ONO-AE1-259 ONO-AE1-329	[83]
EP3	dorsal raphe nucleus	depolarization	M&B 28767	[74]
EP3	paratracheal ganglion	inhibition of ICa	sulprostone	[48]
EP3	trigeminal ganglion	inhibition of ICa	ONO-AE-248	[14]
EP3C/4	dorsal root ganglion	cAMP increase	*	[108]
EP4	supraoptic nucleus	depolarization	ONO-AE1-329	[100]

^*blocked by antisense oligonucleotides.