Fig. (1).

Schematic depiction of the six mammalian thermoTRP channels. Each channel subunit is made up of six putative transmembrane domains with a pore region between segments five and six. The N- and C-termini are thought to be intracellular. All thermoTRPs, except TRPM8, have a variable number of ankyrin repeat domains in the N-terminus. The C-termini of thermoTRPs also contain special features such as a TRP box or PDZ binding domain. All of the thermoTRPs display distinct thermal thresholds from very hot (TRPV2) to cold (TRPA1). Each thermoTRP is also activated by specific botanicals, endogenous and synthetic substances, some of which induce cutaneous thermal and pain sensations.