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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: J Cell Sci. 2008 May 13;121(Pt 11):1869–1875. doi: 10.1242/jcs.027334

Figure 4. BDNF enhanced hippocampal dendrite outgrowth is blocked by Src inhibitors but not by the Crk&CrkL shRNA virus.

Figure 4

BDNF enhances the growth of MAP 2 positive hippocampal dendrites approximately 1.8 fold after 5 days of treatment as compared to growth in neurobasal-B27 media alone. Inclusion of the SFK family kinase inhibitors PP1 and PP2 during incubation prevented the BDNF-induced augmentation of process extension. However reduction of Crk and CrkL expression did not significantly block the BDNF effect on dendrites. The number of neurons measured is indicated at the base of each bar. * P<0.001. Error bars indicate SEM values.