TABLE 1.
Associations of daily intake of choline, methionine, and betaine with risk of breast cancer in the LIBCSP, 1996−1997
| Category | Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | Ptrend |
|---|---|---|---|---|---|---|
| Choline | ||||||
| mg/day | <196.5 | 196.5−280.5 | 280.5−362.9 | 362.9−455.8 | >455.8 | |
| Case | 314 | 296 | 293 | 336 | 240 | |
| Control | 304 | 304 | 305 | 304 | 305 | |
| OR and 95% CI | 1.00 (ref) | 0.91 (0.73−1.15) | 0.91 (0.72−1.15) | 1.04 (0.82−1.31) | 0.76 (0.58−1.00)* | 0.29 |
| Methionine | ||||||
| g/day | <0.65 | 0.65−0.86 | 0.86−1.06 | 1.06−1.34 | >1.34 | |
| Case | 316 | 300 | 301 | 288 | 274 | |
| Control | 305 | 303 | 305 | 304 | 305 | |
| OR and 95% CI | 1.00 (ref) | 0.97 (0.77−1.23) | 0.98 (0.77−1.26) | 0.96 (0.73−1.26) | 0.94 (0.69−1.30) | 0.73 |
| Betaine | ||||||
| mg/day | <66.4 | 66.4−97.2 | 97.2−133.0 | 133.0−201.0 | >201.0 | |
| Case | 319 | 285 | 270 | 320 | 285 | |
| Control | 305 | 303 | 306 | 303 | 305 | |
| OR and 95% CI | 1.00 (ref) | 0.92 (0.73−1.16) | 0.87 (0.69−1.11) | 1.06 (0.83−1.36) | 0.96 (0.74−1.24) | 0.83 |
ORs were adjusted for age and daily energy intake; absolute nutrient intake values were categorized according to quintiles among controls. ref, referent.
*
P < 0.05.