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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Exp Hematol. 2008 Jun;36(6):742–751. doi: 10.1016/j.exphem.2008.03.010

Figure 6. Different strategies to obtain true PSC from non-embryonic tissues.

Figure 6

Panel A – Due to the phenomenon of stem cell plasticity of e.g., monopotent HSC may become other types of stem cells. The phenomenon of stem cell plasticity or transdedifferentiation is not confirmed/supported by recent data. Panel B - Isolation of PSC from adult tissues. Several cell candidates are described but so far not one of them was able to contribute in a reproducible way to blastocyst development. In the case of VSEL a problem could be related to erasure of somatic imprint. Panel C - Nuclear reprogramming leads to a generation of PSC-like cells – known as induced PSC (i-PSC). The selected cellular clones, however, form teratomas in syngeneic animals.