Table 3.

Cytotoxicity and selectivity assessment

Comp.	CD50 (μM)a	SIMtb (CD50/IC50GAST-D)	SIYp (CD50/IC50PMH-D)
1	3	<0.006	<0.3
2	5	<0.01	<1
3	5	<0.01	10
4	6	<0.02	15
5	5	<0.01	7
6	3	0.01	300
7	3	0.04	3
8	3	0.1	4
9	15	<0.03	8
10	1	0.04	1
11	17	0.6	9
12	11	0.4	14
13	42	14	<2
14	1	0.002	0.5
15	4	<0.008	6
16	21	0.7	7
17	3	0.007	3
18	13	<0.03	7
19	11	0.02	11
20	25	<0.05	42
21	15	0.1	5
22	16	<0.03	16
23	63	0.4	63
24	23	0.3	33
25	62	1.0	155
26	30	0.4	50
27	26	0.5	2
28	31	0.2	155
29	248	3	<3
30	19	0.8	<1
31	29	0.06	<0.8
32	398	50	<10
RIF	190	nd	nd
STR	>500	nd	nd
CHX	0.1	nd	nd

^aCD₅₀s were calculated from sigmoidal curves fitted to triplicate sets of dose-response data. SI_Mtb and SI_Yp, selectivity index relative to activity against M. tuberculosis and Y. pestis, respectively. CD₅₀ and SI values <1 and values >1 were rounded to one significant digit and to the nearest non-fractional number, respectively. CHX, cycloheximide. Other abbreviations as in Table 1.