Table 4.
Likelihood of Alzheimer’s disease by ESR1 genotype for women with Down syndrome
| ER-α genotype | n | AD | Model Ia
|
Model IIb
|
|||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | p value | |||
| rs2881766 | |||||||
| GG | 7 | 004 (57.1) | 6.0 | 0.6–57.1 | 11.0 | 0.9–141.4 | 0.06 |
| TG | 53 | 021 (39.6) | 1.1 | 0.4–2.2 | 1.1 | 0.5–2.3 | 0.90 |
| TT | 119 | 047 (39.5) | 1.0 | reference | 1.0 | reference | |
| rs2077647 | |||||||
| CC | 45 | 022 (48.9) | 2.35 | 0.95–5.8 | 2.8 | 1.1–7.4 | 0.04 |
| CT | 88 | 037 (42.0) | 1.8 | 0.80–3.9 | 1.9 | 0.8–4.5 | 0.14 |
| TT | 48 | 015 (20.3) | 1.0 | reference | 1.0 | reference | |
| rs6920483 | |||||||
| GA | 5 | 001 (20.0) | 0.37 | 0.03–5.0 | 0.2 | 0.01–3.6 | 0.28 |
| GG | 169 | 169 (40.8) | 1.0 | reference | 1.0 | reference | |
| rs2234693 | |||||||
| CC | 47 | 023 (48.9) | 2.7 | 1.1–6.9 | 3.2 | 1.2–8.5 | 0.02 |
| CT | 84 | 036 (42.9) | 2.2 | 0.97–4.9 | 2.6 | 1.1–6.2 | 0.04 |
| TT | 50 | 015 (30.0) | 1.0 | reference | 1.0 | reference | |
| rs9340799 | |||||||
| GG | 33 | 015 (45.4) | 1.8 | 0.7–4.7 | 1.7 | 0.8–3.7 | 0.17 |
| AG | 81 | 036 (44.4) | 1.6 | 0.7–3.2 | 2.0 | 0.7–5.3 | 0.19 |
| AA | 65 | 023 (36.3) | 1.0 | reference | 1.0 | reference | |
Percentage values are given in parentheses. The total number of observations may vary because of missing data.
a
Logistic regression, adjusted for age at baseline and ethnicity.
b
Logistic regression, adjusted for age at baseline, ethnicity, level of mental retardation, baseline BMI, history of depression, diabetes, hypertension, heart disease and the presence of the APOE ε4 allele.