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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Pain. 2007 Aug 7;136(1-2):75–84. doi: 10.1016/j.pain.2007.06.017

Fig. 2. Effect of adrenalectomy on the ability of LPS to decrease forelimb grip force measurements and to induce lethality in mice.

Fig. 2

A. Values in the upper panel represent grip force responses (mean±SEM) taken at the times indicated after s.c. injections of 5 mg/kg of LPS or saline in mice that were subjected to either adrenalectomy (ADX) or sham-surgery two weeks before injection. The asterisks indicate the time-intervals at which values from LPS-injected ADX mice (8 hr) and the values from the two groups injected with LPS (24 hr) were significantly less than those in the remaining groups, but not significantly different from each other. Significant differences (P < 0.05) between the groups (n=7) were determined using ANOVA followed by PLSD. Throughout the grip force values shown, standard errors were calculated but are in some cases too small to be depicted.

B. The lower panel illustrates the effect of LPS on lethality in mice 2 weeks after ADX or sham surgery. Values represent the percent of 9 ADX or sham-operated mice that survived each injection of 5 mg/kg of LPS delivered s.c. daily. While sham-operated mice are remarkably resistant to the lethal effects of LPS, several adrenalectomized mice died after the first two injections, illustrating the high sensitivity of ADX mice to endotoxemia.