A. Values in the upper panel represent the grip force responses (mean±SEM) measured at 24 hr after LPS (5 mg/kg s.c.) or saline when administered to mice that were previously adrenalectomized (ADX) or sham-operated (Sham) two weeks previously. The asterisk represents a significant difference (P < 0.05) between the groups indicated, as determined using ANOVA followed by PLSD.
B. Values in the lower panel represent the concentration of circulating corticosterone (mean±SEM) in the same adrenalectomized and sham-operated mice as in the panel above, measured 24 hr after the injection of LPS (5 mg/kg s.c.) or saline. Mice were subjected to a 5-min forced swim at room temperature immediately prior to death to activate adrenal tissue, where present. The asterisk represents a significant difference (P < 0.05) between the groups indicated, as determined using ANOVA followed by PLSD.