FIGURE 4.

Visual representation of factor VIII and factor VIIIa activity decay rates mapped onto the factor VIII structure model. Factor VIII surface model of individual domains are drawn by Swiss PDB viewer as colored by yellow (A1), transparent blue (A2), red (A3), green (C1), and C2 (gray). Boxes indicate the location of side chain atoms of the indicated residues potentially involved in the hydrogen bonding. White boxes indicate that a mutation at a given residue resulted in essentially no effect on the rate of activity decay. Color gradients represent increasing rates of activity decay for factor VIII (white to blue) or factor VIIIa (white to yellow) for the mutated residue.