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Deregulated cyclin E cooperates with low concentrations of FBS to induce DNA synthesis and mitosis. BJ fibroblasts were synchronized by serum starvation and transduced with 150 MOI of adenoviruses expressing cyclin E. After 15 h, cells were restimulated with the indicated concentrations of FBS and harvested at the indicated time points for PI/FACS (A) or Western blot (B) analyses. The Thr-160-phosphorylated form of CDK2 is marked with an asterisk.
