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. 2008 Jul;49(7):1500–1510. doi: 10.1194/jlr.M800053-JLR200

TABLE 3.

Significant and suggestive QTL for plasma TG, FFA, and glucose

LOD Scorec
Locus Namea Chr Peak Mb 95% CI Sex as Additive Covariate Sex as Interactive Covariate Nearest Marker High Allele (Sex)e
Mb
TG
 None 4 43 21–65 2.1 3.2 rs3725792 NZW
 Tgq4 7 101 58–116 3.1 3.5 rs3670069 NZW
 Tgq5 8 21 0–50 3.2 3.4 rs3691954 NZW
 Tgq6 18 68 52–78 4.1 4.5 rs4231907 NZB
 Tgq7b 10 48 — 1.0 1.7 rs3722617 —
 Tgq8b 10 107 — 1.2 2.1 rs13480757 —
FFA
 Ffaq2 4 43 30–60 2.0 5.4d rs3725792 NZW (M)
 None 16 6 0–25 2.7 3.1 rs3090912 NZW
 Ffaq3b 2 69 — 1.2 1.3 rs3726142 —
 Ffaq4b 15 10 0–32 2.3 2.0 rs3676680 NZB
Glucose
 Bglu4 2 72 60–88 2.2 3.6 rs3687515 NZB
 Bglu5 2 145 120–175 2.2 4.3d rs3022911 NZW (M)
 Bglu6 4 32 21–43 1.1 3.5d rs3725792 NZB (M)
 None 7 56 26–78 2.2 2.2 rs3708035 NZB
 Bglu7 10 87 74–100 2.1 3.9d rs3089366 NZW (M)
 Bglu8 15 29 15–70 1.2 4.3d rs4230721 NZW (F), NZB (M)
 Bglu9 17 22 0–45 2.3 4.1 rs4231344 NZB
 Bglu10 18 33 0–50 1.8 3.3 rs3705122 NZB (M)
 Bglu11b 8 24 — 0.4 2.3 rs3691954 —

CI, confidence interval; LOD, logarithm of the odds ratio; QTL, quantitative trait loci.

a

The QTL were named if they were significant or if they were suggestive but confirmed QTL that were found previously. The nomenclature of Bglu and Tgq for blood glucose QTL and triglyceride QTL is adopted from previous QTL for these traits (8, 9). Ffaq is used for FFA QTL.

b

Interacting QTL are selected from pairwise gene interaction search.

c

LOD score values were obtained from single QTL analysis. The suggestive and significant LOD score thresholds were determined by 1,000 permutation tests for each trait, the significant LOD scores were bolded. With sex as additive covariate, the suggestive/significant LODs are 1.9/2.8 for TG, 1.9/2.8 for FFA, and 1.9/2.9 for glucose. With sex as interactive covariate, the suggestive and significant LODs are 2.9/3.7 for TG, 2.9/3.8 for FFA, and 2.3/3.3 for glucose.

d

The LOD difference between sex as additive and interactive models is >2, indicating that the QTL differs between the sexes.

e

The sex is given if it is sex-specific QTL, M for male, F for female. For Bglu8, NZW is high allele in females while NZB is high in males.