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TLX1 blocks human thymocyte differentiation prior to the DP stage. CD34+ human cord blood stem/progenitor cells were transduced with MSCV-GW and TLX1 retroviral vectors and used in hybrid human/murine FTOCs. Thymocytes were harvested and analyzed after 25 days for expression of (A) CD1a and CD2 on GFP−CD45+ and GFP+CD45+ cells, and (B) CD4 and CD8 expression. Bivariate histograms are representative of thymocytes from five thymic lobes.
